诺奖得主David MacMillan教授：光催化下氯代烷烃的斜向亲电偶联反应

; 5 mol% Ni, 1 mol% Ir), and 1,1,3,3-tetramethylguanidine (38 µL, 0.3 mmol, 3.0 equiv.). The reaction mixture was sparged with nitrogen gas for 15 minutes, and the vial was sealed with parafilm and irradiated with a 34 W Kessil H150 Blue LED from 2 cm away for 18 hours, during which the reaction temperature equilibrated at 50–55 ˚C. The reaction was quenched by exposure to air with stirring for 5 minutes. Internal standard (1,3,5-trimethoxybenzene and 1,4-difluorobenzene, 1.0 equiv.) was added to the crude reaction mixture and an aliquot was taken for 1H and 19F NMR analysis in CDCl3. Formation of the desired product was confirmed by comparing the NMR spectra with those of the independently prepared authentic product.

近年来光氧化还原成羧酸还原成C(sp3)-C(sp2)对角胺残基的研究者获取很大的进展。相比传统温造成了的还原成对角胺残基，Ni/光氧化还原成双羧酸体系无需使用分析化学计量的锆过氧化氢，可用不方便，情况下温和。此作法透过更价格便宜的硫代有机衍生物和硫代芳香烃作为残基，有非常好的金融业价值。

参考资料

Cross-Electrophile Coupling of Unactivated Alkyl Chlorides；Holt A. Sakai, Wei Liu, Chi “Chip” Le and David W. C. MacMillan *；J. Am. Chem. Soc. 2020, 142, 27, 11691–11697；

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